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  1. Scholars Hub of the Academia Sinica
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Browsing by Author Chern, J. W.


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Showing results 1 to 17 of 17
Issue DateTitleAuthor(s)RelationscopusWOSFulltext/Archive link
19943-beta-D-ribofuranosyl-6,7-dihydro-9H-thiazolo[3,2-a]purin-9-one hydrateLiaw, Y. C. ; Wang, A. H. J.; Lin, G. S.; Chern, J. W.Acta Crystallogr C 50, 734-736
1999Accelerated clearance of polyethylene glycol-modified proteins by anti-polyethylene glycol IgMCheng, T. L.; Wu, P. Y.; Wu, M. F.; Chern, J. W.; Roffler, S. R.Bioconjugate Chemistry 10, 520-528
1991Anti-neoplastic glucuronide prodrug treatment of human tumor cells targeted with a monoclonal antibody-enzyme conjugateRoffler, S. R.; Wang, S. M.; Chern, J. W.; Yeh, M. Y.; Tung, E.Biochem Pharmacol 42, 2062-2065
2002Anti-tumour activity and toxicity of the new prodrug 9-aminocamptothecin glucuronide (9ACG) in micePrijovich, Z. M.; Chen, B. M.; Leu, Y. L.; Chern, J. W.; Roffler, S. R.British Journal of Cancer 86, 1634-1638
1999Bystander killing of tumour cells by antibody-targeted enzymatic activation of a glucuronide prodrugCheng, T. L.; Wei, S. L.; Chen, B. M.; Chern, J. W.; Wu, M. F.; Liu, P. W.; Roffler, S. R.British Journal of Cancer 79, 1378-1385
1999Characterization of an antineoplastic glucuronide prodrugCheng, T. L.; Chou, W. C.; Chen, B. M.; Chern, J. W.; Roffler, S. R.Biochem Pharmacol 58, 325-328
1997Cure of malignant ascites and generation of protective immunity by monoclonal antibody-targeted activation of a glucuronide prodrug in ratsChen, B. M.; Chan, L. Y.; Wang, S. M.; Wu, M. F.; Chern, J. W.; Roffler, S. R.Int J Cancer 73, 392-402
1999Design and synthesis of water-soluble glucuronide derivatives of camptothecin for cancer prodrug monotherapy and antibody-directed enzyme prodrug therapy (ADEPT)Leu, Y. L.; Roffler, S. R.; Chern, J. W.J Med Chem 42, 3623-3628
2000Efficient clearance of poly(ethylene glycol)-modified immunoenzyme with anti-PEG monoclonal antibody for prodrug cancer therapyCheng, T. L.; Chen, B. M.; Chern, J. W.; Wu, M. F.; Roffler, S. R.Bioconjugate Chemistry 11, 258-266
1992Heterocyclic Compounds. I. Reactions of o-amino-carboxamide with b-diketones: Synthesis of Imidazo[1,5-a]pyrimidine and Pyrazolo[1,5-a]pyrimidine DerivativesChern, J. W.; Lee, C. C.; Liaw, Y. C. ; Wang, A. H. J.Heterocycles 34, 1133-1145
1997Poly(ethylene glycol) modification of beta-glucuronidase-antibody conjugates for solid-tumor therapy by targeted activation of glucuronide prodrugsCheng, T. L.; Chen, B. M.; Chan, L. Y.; Wu, P. Y.; Chern, J. W.; Roffler, S. R.Cancer Immunol Immunother 44, 305-315
2003Proactive antitumor compoundsRoffler, S. R.; Chern, J. W.; Leu, Y. L.European Patent EP0990661
2000Proactive antitumor compoundsRoffler, S. R.; Chern, J. W.; Leu, Y. L.US Patent #6,043,367
1992Specific activation of glucuronide prodrugs by antibody-targeted enzyme conjugates for cancer therapyWang, S. M.; Chern, J. W.; Yeh, M. Y.; Ng, J. C.; Tung, E.; Roffler, S. R.Cancer Res 52, 4484-4491
1993Studies on 1,2,4-Benzothiadiazine 1,1-dioxides VII and Quinazolinones IV: Synthesis of Novel Built-in Hydroxyguanine Tricycles as Potential Anticancer AgentsChern, J. W.; Liaw, Y. C. ; Chen, C. S.; Rong, J. G.; Huang, C. L.; Chan, C. H.; Wang, A. H. J.Heterocycles 36, 1091-1103
1997Synthesis and cytotoxic evaluation of substituted sulfonyl-N-hydroxyguanidine derivatives as potential antitumor agentsChern, J. W.; Leu, Y. L.; Wang, S. S.; Jou, R.; Lee, C. F.; Tsou, P. C.; Hsu, S. C.; Liaw, Y. C. ; Lin, H. M.J Med Chem 40, 2276-2286
1992Unusual conformational flexibility in N1-substituted uncommon purine nucleosides. Crystal structure of 1-allyl-isoguanosine and 1-allyl-xanthosineLiaw, Y. C. ; Chern, J. W.; Lin, G. S.; Wang, A. H. J.FEBS Lett 297, 4-8
Showing results 1 to 17 of 17
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