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Browsing by Author Bruzik, K. S.


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Issue DateTitleAuthor(s)RelationscopusWOSFulltext/Archive link
1987A calorimetric study of the thermotropic behavior of pure sphingomyelin diastereomersBruzik, K. S.; Tsai, M. D. Biochemistry 26, 5364-5368
2003Application of Bronsted-type LFER in the study of the phospholipase C mechanismMihai, C.; Kravchuk, A. V.; Tsai, M. D. ; Bruzik, K. S.J Am Chem Soc 125, 3236-3242
1994Are D- and L-chiro-phosphoinositides substrates of phosphatidylinositol-specific phospholipase C?Bruzik, K. S.; Hakeem, A. A.; Tsai, M. D. Biochemistry 33, 8367-8374
1987Biophosphates and Their Analogues, Synthesis, Structure, Metabolism and ActivityTsai, M. D. ; Bruzik, K. S.; Wisner, D.; Liu, S. H.
1992Efficient and Systematic Syntheses of Enantiomerically Pure and Regiospecifically Protected MyoinositolsBruzik, K. S.; Tsai, M. D. J Am Chem Soc 114, 6361-6374
2003Engineering a catalytic metal binding site into a calcium-independent phosphatidylinositol-specific phospholipase C leads to enhanced stereoselectivityKravchuk, A. V.; Zhao, L.; Bruzik, K. S.; Tsai, M. D. Biochemistry 42, 2422-2430
1999Identification of a novel catalytic triad with dual functions in enzymatic cleavage of the P-O bondKubiak, R. J.; Hondal, R. J.; Yue, X. J.; Tsai, M. D. ; Bruzik, K. S.J Am Chem Soc 121, 488-489
2001Involvement of the Arg-Asp-His catalytic triad in enzymatic cleavage of the phosphodiester bondKubiak, R. J.; Yue, X.; Hondal, R. J.; Mihai, C.; Tsai, M. D. ; Bruzik, K. S.Biochemistry 40, 5422-5432
1998Mechanism of phosphatidylinositol-specific phospholipase C: a unified view of the mechanism of catalysisHondal, R. J.; Zhao, Z.; Kravchuk, A. V.; Liao, H.; Riddle, S. R.; Yue, X.; Bruzik, K. S.; Tsai, M. D. Biochemistry 37, 4568-4580
2001Mechanism of phosphatidylinositol-specific phospholipase C: origin of unusually high nonbridging thio effectsKravchuk, A. V.; Zhao, L.; Kubiak, R. J.; Bruzik, K. S.; Tsai, M. D. Biochemistry 40, 5433-5439
1998Mechanism of PI-Specific Phospholipase C. 5. Revealed by Protein Engineering and Phosphorothioate Analogs of PhosphatidylinositolHondal, R. J.; Zhao, Z.; Kravchuk, A. V.; Liao, H.; Riddle, S. R.; Bruzik, K. S.; Tsai, M. D. In: Phosphoinositides: Chemistry, Biochemistry and Biomedical Applications 718, 109-120
1997Phosphatidylinositol-specific phospholipase C .3. Elucidation of the catalytic mechanism and comparison with ribonuclease A1Hondal, R. J.; Zhao, Z.; Riddle, S. R.; Kravchuk, A. V.; Liao, H.; Bruzik, K. S.; Tsai, M. D. J Am Chem Soc 119, 9933-9934
1997Phosphatidylinositol-specific phospholipase C: kinetic and stereochemical evidence for an interaction between arginine-69 and the phosphate group of phosphatidylinositolHondal, R. J.; Riddle, S. R.; Kravchuk, A. V.; Zhao, Z.; Liao, H.; Bruzik, K. S.; Tsai, M. D. Biochemistry 36, 6633-6642
1991Phospholipase stereospecificity at phosphorusBruzik, K. S.; Tsai, M. D. Methods in Enzymology 197, 258-269
1983Phospholipids Chiral at Phosphorus - Synthesis, Absolute-Configurations and ApplicationsBruzik, K. S.; Jiang, R. T.; Tsai, M. D. Phosphorus Sulfur and Silicon and the Related Elements 18, 369-372
1987Phospholipids Chiral at Phosphorus. 14. Stereochemical Effects on the Thermotropic Properties of Thiophosphatidylcholines and ThiosphingomyelinsTsai, M. D. ; Bruzik, K. S.; Wisner, D.; Liu, S. H.In: Biophosphates and Their Analogues, Synthesis, Structure, Metabolism and Activity 561-570
1992Phospholipids chiral at phosphorus. Stereochemical mechanism for the formation of inositol 1-phosphate catalyzed by phosphatidylinositol-specific phospholipase CBruzik, K. S.; Morocho, A. M.; Jhon, D. Y.; Rhee, S. G.; Tsai, M. D. Biochemistry 31, 5183-5193
1991Phosphorothioate Analogs of Phosphatidylinositol and Inositol 1,2-Cyclic Phosphate - Application to the Mechanism of Phospholipase-CBruzik, K. S.; Lin, G. L.; Tsai, M. D. ACS Symposium Series 463, 172-185
1992Practical Synthesis of Enantiomerically Pure myo-Inositol DerivativesBruzik, K. S.; Myers, J.; Tsai, M. D. Tetrahedron Lett 33, 1009-1012
1996Synthesis of inositol phosphodiesters by phospholipase C-catalyzed transesterificationBruzik, K. S.; Guan, Z. W.; Riddle, S.; Tsai, M. D. J Am Chem Soc 118, 7679-7688
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