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  1. Scholars Hub of the Academia Sinica
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Browsing by Author Leu, YL


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Showing results 1 to 11 of 11
Issue DateTitleAuthor(s)RelationscopusWOSFulltext/Archive link
2011A humanized immunoenzyme with enhanced activity for glucuronide prodrug activation in the tumor microenvironment.Chen, KC; Wu, SY; Leu, YL; Prijovich, ZM; Chen, BM; Wang, HE; Cheng, TL; Roffler, SRBioconjugate chemistry 22(5), 938-948
2012An activity-based near-infrared glucuronide trapping probe for imaging beta-glucuronidase expression in deep tissues.Cheng, TC; Roffler, SR; Tzou, SC; Chuang, KH; Su, YC; Chuang, CH; Kao, CH; Chen, CS; Harn, IH; Liu, KY; Cheng, TL; Leu, YLJournal of the American Chemical Society 134(6), 3103-3110
2009Antiangiogenesis targeting tumor microenvironment synergizes glucuronide prodrug antitumor activity.Juan, TY; Roffler, SR; Hou, HS; Huang, SM; Chen, KC; Leu, YL; Prijovich, ZM; Yu, CP; Wu, CC; Sun, GH; Cha, TLCLINICAL CANCER RESEARCH 15(14), 4600-4611
2008Directed evolution of a lysosomal enzyme with enhanced activity at neutral pH by mammalian cell-surface display.Chen, KC; Wu, CH; Chang, CY; Lu, WC; Tseng, Q; Prijovich, ZM; Schechinger, W; Liaw, YC ; Leu, YL; Roffler, SR Chemistry & Biology 15(12), 1277-1286
2015Discovery of Specific Inhibitors for Intestinal E. coli beta-Glucuronidase through In Silico Virtual Screening.Cheng, TC; Chuang, KH; Roffler, SR; Cheng, KW; Leu, YL; Chuang, CH; Huang, CC; Kao, CH; Hsieh, YC; Chang, LS; Cheng, TL; Chen, CSTheScientificWorldJournal 2015, 740815
2012ECSTASY, an adjustable membrane-tethered/soluble protein expression system for the directed evolution of mammalian proteins.Chen, CP; Hsieh, YT; Prijovich, ZM; Chuang, HY; Chen, KC; Lu, WC; Tseng, Q; Leu, YL; Cheng, TL; Roffler, SRPROTEIN ENGINEERING DESIGN & SELECTION 25(7), 367-375
2011Enhancement of CPT-11 antitumor activity by adenovirus-mediated expression of beta-glucuronidase in tumors.Huang, PT; Chen, KC; Prijovich, ZM; Cheng, TL; Leu, YL; Roffler, SRCancer gene therapy 18(6), 381-389
2022Inhibition of gut microbial β-glucuronidase effectively prevents carcinogen-induced microbial dysbiosis and intestinal tumorigenesisCheng, KW; Tseng, CH; Chen, IJ; Huang, BC; Liu, HJ; Ho, KW; Lin, WW; Chuang, CH; Huang, MY; Leu, YL; Roffler, SR ; Wang, JY; Chen, YL; Cheng, TLPharmacological research 177, 106115
2014PET Imaging of beta-Glucuronidase Activity by an Activity-Based 124I-Trapping Probe for the Personalized Glucuronide Prodrug Targeted Therapy.Su, YC; Cheng, TC; Leu, YL; Roffler, SR; Wang, JY; Chuang, CH; Kao, CH; Chen, KC; Wang, HE; Cheng, TLMolecular Cancer Therapeutics 13(12), 2852-2863
2016Synthesis and Antitumor Properties of BQC-Glucuronide, a Camptothecin Prodrug for Selective Tumor Activation.Prijovich, ZM; Burnouf, PA; Chou, HC; Huang, PT; Chen, KC; Cheng, TL; Leu, YL; Roffler, SRMolecular pharmaceutics 13(4), 1242-50
2013The anaerobic and aerobic cleavage of the steroid core ring structure by Steroidobacter denitrificans.Wang, PH; Leu, YL; Ismail, W; Tang, SL; Tsai, CY; Chen, HJ; Kao, AT; Chiang, YR JOURNAL OF LIPID RESEARCH 54:1493-1504
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