Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale

Xihao Li; Zilin Li; Hufeng Zhou; Sheila M. Gaynor; Yaowu Liu; Han Chen; Ryan Sun; Rounak Dey; Donna K. Arnett; Stella Aslibekyan; Christie M. Ballantyne; Lawrence F. Bielak; John Blangero; Eric Boerwinkle; Donald W. Bowden; Jai G. Broome; Matthew P. Conomos; Adolfo Correa; L. Adrienne Cupples; Joanne E. Curran; Barry I. Freedman; Xiuqing Guo; George Hindy; Marguerite R. Irvin; Sharon L. R. Kardia; Sekar Kathiresan; Alyna T. Khan; Charles L. Kooperberg; Cathy C. Laurie; X. Shirley Liu; Michael C. Mahaney; Ani W. Manichaikul; Lisa W. Martin; Rasika A. Mathias; Stephen T. McGarvey; Braxton D. Mitchell; May E. Montasser; Jill E. Moore; Alanna C. Morrison; Jeffrey R. O’Connell; Nicholette D. Palmer; Akhil Pampana; Juan M. Peralta; Patricia A. Peyser; Bruce M. Psaty; Susan Redline; Kenneth M. Rice; Stephen S. Rich; Jennifer A. Smith; Hemant K. Tiwari; Michael Y. Tsai; Ramachandran S. Vasan; Fei Fei Wang; Daniel E. Weeks; Zhiping Weng; James G. Wilson; Lisa R. Yanek; Yi-Cheng Chang; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium; TOPMed Lipids Working Group; Benjamin M. Neale; Shamil R. Sunyaev; Gonçalo R. Abecasis; Jerome I. Rotter; Cristen J. Willer; Gina M. Peloso; Pradeep Natarajan; Xihong Lin

Please use this identifier to cite or link to this item: http://ir.sinica.edu.tw/handle/201000000A/82194

Title:	Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale
Authors:	Xihao Li Zilin Li Hufeng Zhou Sheila M. Gaynor Yaowu Liu Han Chen Ryan Sun Rounak Dey Donna K. Arnett Stella Aslibekyan Christie M. Ballantyne Lawrence F. Bielak John Blangero Eric Boerwinkle Donald W. Bowden Jai G. Broome Matthew P. Conomos Adolfo Correa L. Adrienne Cupples Joanne E. Curran Barry I. Freedman Xiuqing Guo George Hindy Marguerite R. Irvin Sharon L. R. Kardia Sekar Kathiresan Alyna T. Khan Charles L. Kooperberg Cathy C. Laurie X. Shirley Liu Michael C. Mahaney Ani W. Manichaikul Lisa W. Martin Rasika A. Mathias Stephen T. McGarvey Braxton D. Mitchell May E. Montasser Jill E. Moore Alanna C. Morrison Jeffrey R. O’Connell Nicholette D. Palmer Akhil Pampana Juan M. Peralta Patricia A. Peyser Bruce M. Psaty Susan Redline Kenneth M. Rice Stephen S. Rich Jennifer A. Smith Hemant K. Tiwari Michael Y. Tsai Ramachandran S. Vasan Fei Fei Wang Daniel E. Weeks Zhiping Weng James G. Wilson Lisa R. Yanek Yi-Cheng Chang NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium TOPMed Lipids Working Group Benjamin M. Neale Shamil R. Sunyaev Gonçalo R. Abecasis Jerome I. Rotter Cristen J. Willer Gina M. Peloso Pradeep Natarajan Xihong Lin
Issue Date:	2020
Relation:	Nature Genetics 52, 969-983
URI:	http://ir.sinica.edu.tw/handle/201000000A/82194
ISSN:	http://gateway.isiknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=Drexel&SrcApp=hagerty_opac&KeyRecord=1061-4036&DestApp=JCR&RQ=IF_CAT_BOXPLOT
URL:	http://dx.doi.org/10.1038/s41588-020-0676-4
Appears in Collections:	生物醫學科學研究所

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