Results 1-105 of 105 (Search time: 0.002 seconds).
| Issue Date | Title | Author(s) | Relation | scopus | WOS | Fulltext/Archive link | |
|---|---|---|---|---|---|---|---|
| 1 | 2008 | A mammalian cell-based reverse two-hybrid system for functional analysis of 3C viral protease of human enterovirus 71 | Lee, JC; Shih, SR; Chang, TY; Tseng, HY; Shih, YF; Yen, KJ; Chen, WC; Shie, JJ; Fang, JM; Liang, PH ; Chao, YS; Hsu, JT | Anal Biochemistry 375, 115-123 | |||
| 2 | 2004 | A molecular ruler for chain elongation catalyzed by octaprenyl pyrophosphate synthase and its structure-based engineering to produce unprecedented long chain trans-prenyl products | Guo, RT; Kuo, CJ; Ko, TP; Chou, CC; Liang, PH ; Wang, AHJ | Biochemistry 43(24), 7678-7686 | |||
| 3 | 2005 | A novel substrate binding mode revealed by the site-directed mutagenesis studies of E. coli octaprenyl pyrophosphate synthase | Kuo, CJ; Guo, RT; Li, SC; Chang, KM; Wang, AHJ ; Liang, PH | Biochemistry submitted | |||
| 4 | 2006 | An E. coli lon mutant conferring partial resistance to colicin may reveal a novel role in regulating proteins involved in the translocation of colicin | Lee, YY; Hu, HT; Liang, PH ; Chak, KF | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 345, 1579-1585 | |||
| 5 | 1992 | Ancestry of the 4-chlorobenzoate dehalogenase: Analysis of amino acid sequence identities among families of acyl: adenyl ligase, enoyl-CoA hydratase/isomerase, and acyl-CoA thioesterase | Babbitt, PC; Kenyon, GL; Martin, BM; Charest, H; Slyvestre, M; Scholten, JD; Chang, KH; Liang, PH ; Dunaway-Mariano, D | Biochemistry 31, 5594-5604 | |||
| 6 | 2015 | Biochemical Characterization and Structural Analysis of a Bifunctional Cellulase/Xylanase from Clostridium thermocellum. | Yuan, SF; Wu, TH; Lee, HL; Hsieh, HY; Lin, WL; Yang, B; Chang, CK; Li, Q; Gao, J; Huang, CH; Ho, MC ; Guo, RT; Liang, PH | The Journal of biological chemistry 290(9), 5739-5748 | |||
| 7 | 2007 | Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases | Guo, RT; Cao, R; Liang, PH ; Ko, TP; Chang, TH; Hudock, MP; Jeng, WY; Chen, CK; Zhang, Y; Song, Y; Kuo, CJ; Yin, F; Oldfield, E; Wang, AHJ | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 104(24), 10022-10027 | |||
| 8 | 1997 | Catalytic Mechanism of KDO8P Synthase, Pre-Steady-State Kinetic Analysis Using Rapid Chemical Quench Flow Methods | Liang, PH ; Kohen, A; Baasov, T; Anderson, KS | Bioorg Med Chem Lett 7, 2463-2468 | |||
| 9 | 1998 | Catalytic Mechanism of Kdo8P Synthase: Transient Kinetic Studies and Evaluation of a Putative Reaction Intermediate | Liang, PH ; Lewis, J; Anderson, KS; Kohen, A; D’Souza, FW; Benenson, Y; Baasov, T | Biochemistry 37, 16390-16399 | |||
| 10 | 2003 | Catalytic mechanism revealed by the crystal structure of undecaprenyl pyrophosphate synthase in complex with sulfate, magnesium, and triton | Chang, SY; Ko, TP; Liang, PH ; Wang, AHJ | The Journal of biological chemistry 278(31), 29298-29307 | |||
| 11 | 2006 | Characterization and inhibition of SARS-coronavirus main protease | Liang, PH | Current Topics in Medicinal Chemistry 6, 361-376 | |||
| 12 | 2004 | Characterization of SARS main protease and inhibitor assay using a fluorogenic substrate | Kuo, CJ; Chi, YH; Hsu, JT; Liang, PH | Biochem Biophys Res Commun 318, 862-867 | |||
| 13 | 2002 | Characterization of the L399P and R447G mutants of hsc70: the decrease in refolding activity is correlated with an increase in the rate of substrate dissociation | Hu, S. M.; Liang, P. H. ; Hsiao, C. D. ; Wang, C. | Arch Biochem Biophys 407(1), 135-141 | |||
| 14 | 2009 | Combined experimental and theoretical study of long-range interactions modulating dimerization and activity of yeast geranylgeranyl diphosphate synthase | Lo, CH; Chang, YH; Wright, JD; Chen, SH; Kan, D; Lim, C; Liang, PH | Journal of the American Chemical Society 131, 4051-4062 | |||
| 15 | 2011 | Construction and characterization of different fusion proteins between cellulases and β-glucosidase to improve glucose production and thermostability. | Lee, HL; Chang, CK; Teng, KH; Liang, PH | BIORESOURCE TECHNOLOGY 102(4), 3973-3976 | |||
| 16 | 2004 | Crystal structure of octaprenyl pyrophosphate synthase from hyperthermophilic Thermotoga maritima and mechanism of product chain length determination | Guo, RT; Kuo, CJ; Chou, CC; Ko, TP; Shr, HL; Liang, PH ; Wang, AHJ | The Journal of biological chemistry 279(6), 4903-4912 | |||
| 17 | 2006 | Crystal structure of type-III geranylgeranyl pyrophosphate synthase from Saccharomyces cerevisiae and the mechanism of product chain length determination | Chang, TH; Guo, RT; Ko, TP; Wang, AHJ ; Liang, PH | The Journal of biological chemistry 281(21), 14991-15000 | |||
| 18 | 2015 | Crystal structures of ligand-bound octaprenyl pyrophosphate synthase from Escherichia coli reveal the catalytic and chain-length determining mechanisms. | Han, X; Chen, CC; Kuo, CJ; Huang, CH; Zheng, Y; Ko, TP; Zhu, Z; Feng, X; Wang, K; Oldfield, E; Wang, AH ; Liang, PH ; Guo, RT; Ma, Y | Proteins 83(1), 37-45 | |||
| 19 | 2005 | Crystal structures of undecaprenyl pyrophosphate synthase in complex with magnesium, isopentenyl pyrophosphate, and farnesyl thiopyrophosphate: roles of the metal ion and conserved residues in catalysis | Guo, RT; Ko, TP; Chen, AP; Kuo, CJ; Wang, AHJ ; Liang, PH | Journal of Biological Chemistry 280(21), 20762-20774 | |||
| 20 | 1999 | Crystallographic Studies of Phosphonat-Based alpha-reaction transition-State Analogues Complexed to Tryptophan Synthase | Sachpatzidis, A; Dealwis, C; Lubetsky, JB; Liang, PH ; Anderson, KS; Lolis, E | Biochemistry 38, 12665-12674 | |||
| 21 | 2008 | Design, synthesis, and evaluation of 3C protease inhibitors as anti-enterovirus 71 agents | Kuo, CJ; Shie, JJ; Fang, JM; Yen, GR; Hsu, JT; Liu, HG; Tseng, SN; Chang, SC; Lee, CY; Shih, SR; Liang, PH | BIOORGANIC & MEDICINAL CHEMISTRY 16, 7388-7398 | |||
| 22 | 2008 | Design, Synthesis, and Evaluation of Trifluoromethyl Ketones as Inhibitors of SARS-CoV 3CL Protease | Shao, Y. -M.; Yang, W. -B. ; Kuo, T. -H.; Tsai, K. -C.; Lin, C. -H. ; Yang, A. -S. ; Liang, P. -H. ; Wong, C. -H. | Bioorganic & Medicinal Chemistry 16(8), 4652-4660 | |||
| 23 | 2009 | Different reaction mechanisms for cis- and trans-prenyltransferases. | Lu, YP; Liu, HG; Liang, PH | Biochemical and biophysical research communications 379(2), 351-355 | |||
| 24 | 2006 | Discovery of a novel family of SARS-CoV protease inhibitors by virtual screening and 3D-QSAR studies | Tsai, KC; Chen, SY; Liang, PH ; Lu, IL; Mahindroo, N; Hsieh, HP; Chao, YS; Liu, L; Liu, D; Lien, W; Lin, TH; Wu, SY | J Med Chem 49, 3485-3495 | |||
| 25 | 2005 | Discovery of Potent Anilide Inhibitors against the Severe Acute Respiratory Syndrome 3CL Protease | Shie, JJ; Fang, JM; Kuo, CJ; Kuo, TH; Liang, PH ; Huang, HJ; Yang, WB ; Lin, CH ; Chen, JL; Wu, YT; Wong, CH | Journal of Medicinal Chemistry 48(13), 4469-4473 | |||
| 26 | 2004 | DNA Binding and Degradation by the HNH Protein ColE7 | Hsia, K. C.; Chak, K. F.; Liang, P. H. ; Cheng, Y. S.; Ku, W. Y.; Yuan, H. S. | Structure 12(2), 205-214 | |||
| 27 | 2007 | Drug discovery for SARS and other human coronaviruses targeting 3C proteases | Liang, PH | Drugs of the Future 32, 29-29 | |||
| 28 | 2000 | Effect of site-directed mutagenesis of the conserved aspartate and glutamate on E. coli undecaprenyl pyrophosphate synthase catalysis | Pan, JJ; Yang, LW; Liang, PH | Biochemistry 39, 13856-13861 | |||
| 29 | 2009 | Engineering a novel endopeptidase based on SARS 3CLpro | Kuo, CJ; Shih, YP; Kan, D; Liang, PH | BioTechniques 47(6), 1029–1032 | |||
| 30 | 2004 | Evaluation of metal-conjugated compounds as inhibitors of 3CL protease of SARS-CoV | Hsu, JT; Kuo, CJ; Hsieh, HP; Wang, YC; Huang, KK; Lin, CP; Huang, PF; Chen, X; Liang, PH | FEBS Lett 574, 116-120 | |||
| 31 | 1995 | Evidence for Electrophilic Catalysis in the 4-Chlorobenzoyl-CoA Dehalogenase Reaction: UV, Raman and C-13 NMR Spectral Studies of Dehalogenase Complexes of Benzoyl-CoA Adducts | Taylor, KL; Liu, RQ; Liang, PH ; Price, J; Dunaway-Mariano, D; Tonge, PJ; Clarkson, J; Carey, PR | Biochemistry 34, 13881-13888 | |||
| 32 | 1994 | Evidence for Nucleophilic Catalysis in the Aromatic Substitution Reaction Catalyzed by (4-Chlorobenzoyl) coenzyme A dehalogenase | Yang, G; Liang, PH ; Dunaway-Mariano, D | Biochemistry 33, 8527-8531 | |||
| 33 | 2016 | Fluorescent Farnesyl Diphosphate Analogue: A Probe To Validate trans-Prenyltransferase Inhibitors. | Kuo-Hsun Teng; Erh-Ting Hsu; Ying-Hsuan Chang; Sheng-Wei Lin ; Po-Huang Liang | BIOCHEMISTRY 55(31), 4366-4374 | |||
| 34 | 2011 | Fluorescent substrate analog for monitoring chain elongation by undecaprenyl pyrophosphate synthase in real time. | Teng, KH; Chen, AP; Kuo, CJ; Li, YC; Liu, HG; Chen, CT; Liang, PH | Analytical biochemistry 417(1), 136-141 | |||
| 35 | 2005 | Homodimeric hexaprenyl pyrophosphate synthase from the thermoacidophilic crenarchaeon Sulfolobus solfataricus displays asymmetric subunit structures. | Sun, HY; Ko, TP; Kuo, CJ; Guo, RT; Chou, CC; Liang, PH ; Wang, AHJ | Journal of Bacteriology 187(23), 8137-8148 | |||
| 36 | 2003 | Identification of the active conformation and the importance of length of the flexible loop 72-83 in regulating the conformational change of undecaprenyl pyrophosphate synthase | Chang, SY; Chen, YK; Wang, AHJ ; Liang, PH | Biochemistry 42(49), 14452-14459 | |||
| 37 | 2016 | Identification, synthesis and evaluation of SARS-CoV and MERS-CoV 3C-like protease inhibitors. | Kumar, V; Tan, KP; Wang, YM; Lin, SW ; Liang, PH | Bioorganic & medicinal chemistry 24(13), 3035-3042 | |||
| 38 | 2004 | In vitro modification of human centromere protein CENP-C fragments by small ubiquitin-like modifier (SUMO) protein: definitive identification of the modification sites by tandem mass spectrometry analysis of the isopeptides. | Chung, TL; Hsiao, HH; Yeh, YY; Shia, HL; Chen, YL; Liang, PH ; Wang, AH ; Khoo, KH ; Shoei-Lung, Li S | The Journal of biological chemistry 279(38), 39653-39662 | |||
| 39 | 2009 | Individual and common inhibitors of coronavirus and picornavirus main proteases. | Kuo, CJ; Liu, HG; Lo, YK; Seong, CM; Lee, KI; Jung, YS; Liang, PH | FEBS letters 583(3), 549-555 | |||
| 40 | 2008 | Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation. | Chen, C K-M; Hudock, MP; Zhang, Y; Guo, RT; Cao, R; No, JH; Liang, PH ; Ko, TP; Chang, TH; Chang, SC; Song, Y; Axelson, J; Kumar, A; Wang, AHJ ; Oldfield, E | Journal of medicinal chemistry 51(18), 5594-5607 | |||
| 41 | 2005 | Inhibition of SARS-CoV 3C-like Protease Activity by Theaflavin-3,3′-digallate (TF3) | Chen, CN; Lin, CP; Huang, KK; Chen, WC; Hsieh, HP; Liang, PH ; Hsu, JT | Evid Based Complement Alternat Med 2(2), 209-215 | |||
| 42 | 2005 | Inhibition of the severe acute respiratory syndrome 3CL protease by peptidomimetic alpha,beta-unsaturated esters. | Shie, JJ; Fang, JM; Kuo, TH; Kuo, CJ; Liang, PH ; Huang, HJ; Wu, YT; Jan, JT; Cheng, YS; Wong, CH | BIOORGANIC & MEDICINAL CHEMISTRY 13, 5240-5252 | |||
| 43 | 2002 | Insight into the activation mechanism of Escherichia coli octaprenyl pyrophosphate synthase derived from pre-steady-state kinetic analysis | Pan, JJ; Kuo, TH; Chen, YK; Yang, LW; Liang, PH | BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY 1594, 64-73 | |||
| 44 | 2012 | Insights into the Mechanism of the Antibiotic-Synthesizing Enzyme MoeO5 from Crystal Structures of Different Complexes. | Ren, F; Ko, TP; Feng, X; Huang, CH; Chan, HC; Hu, Y; Wang, K; Ma, Y; Liang, PH ; Wang, AH; Oldfield, E; Guo, RT | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 51(17), 4157-4160 | |||
| 45 | 2009 | Intracellular beta-tubulin/Chaperonin containing TCP1-beta complex serves as a novel chemotherapeutic target against drug-resistant tumors | Lin, YF; Tsai, WP; Liu, HG; Liang, PH | Cancer Research 69, 6879-6888 | |||
| 46 | 2004 | Involvement of colicin in the limited protection of the colicin producing cells against bacteriophage | Lin, YH; Liao, CC; Liang, PH ; Yuan, HS ; Chak, KF | Biochemical and Biophysical Research Communications 318(1), 81-87 | |||
| 47 | 1992 | Isolation and characterization of the three polypeptide components of 4-chlorobenzoate dehalogenase from Pseudomonas sp. Strain CBS-3 | Chang, KH; Liang, PH ; Beck, W; Scholten, JD; Dunaway-Mariano, D | Biochemistry 31, 5605-5610 | |||
| 48 | 1998 | Kinetic Reaction Scheme for the Dihydrofolate Reductase Domain of the Bifunctional Thymidylate Synthase - Dihydrofolate Reductase from Leishmania Major | Liang, PH ; Anderson, KS | Biochemistry 37, 12206-12212 | |||
| 49 | 2011 | Kinetic, mechanistic, structural and inhibitory aspects of the cis-prenyltransferase catalyzed lipid chain elongation. | Liang, PH | CHEMISTRY AND PHYSICS OF LIPIDS 164(S1), S12-S14 | |||
| 50 | 2010 | Learning to predict expression efficacy of vectors in recombinant protein production | Chan, WC; Liang, PH ; Shih, YP; Yang, UC; Lin, WC; Hsu, CN | BMC Bioinformatics 11(Suppl 1), S21 | |||
| 51 | 1998 | Leishmania Major Pteridine Reductase 1 Belongs to the Short Chain Dehydrogenase Family: Stereochemical and Kinetic Evidence | Luba, J; Nare, B; Liang, PH ; Anderson, KS; Beverley, SM; Hardy, LW | Biochemistry 37, 4093-4104 | |||
| 52 | 2006 | Ligand specificities and structural requirements of two Tachypleus plasma lectins for bacterial trapping | Kuo, TH; Chuang, SC; Chang, SY; Liang, PH | Biochem J 393, 757-766 | |||
| 53 | 1998 | Loop Closure and Intersubunit Communication in Tryptophan Synthase | Schneider, TR; Gerhardt, E; Lee, M; Liang, PH ; Anderson, KS; Schlichting, I | Biochemistry 37, 5394-5406 | |||
| 54 | 2010 | Mechanism of cis-prenyltransferase reaction probed by substrate analogues | Lu, YP; Liu, HG; Teng, KH; Liang, PH | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 400(4), 758-762 | |||
| 55 | 2001 | Mechanism of Product Chain Length Determination and the Role of a Flexible Loop in Escherichia coliUndecaprenyl-pyrophosphate Synthase Catalysis | Ko, TP; Chen, YK; Robinson, H; Tsai, PC; Gao, YG; Chen, AP; Wang, AHJ ; Liang, PH | The Journal of biological chemistry 276(50), 47474-47482 | |||
| 56 | 2005 | Mechanism of the maturation process of SARS-CoV 3CL protease | Hsu, MF; Kuo, CJ; Chang, KT; Chang, HC; Chou, CC; Ko, TP; Shr, HL; Chang, GG; Wang, AHJ ; Liang, PH | Journal of Biological Chemistry 280(35), 31257-31266 | |||
| 57 | 2012 | Mutations in the substrate entrance region of β-glucosidase from Trichoderma reesei improve enzyme activity and thermostability | Lee, HL; Chang, CK; Jeng, WY; Wang, AH ; Liang, PH | Protein engineering design & selection 25(11), 733-740 | |||
| 58 | 2007 | Novel small-molecule inhibitors of transmissible gastroenteritis virus | Yang, CW; Yang, YN; Liang, PH ; Chen, CM; Chen, WL; Chang, HY; Chao, YS; Lee, SJ | Antimicrob Agents Chemother 51(11), 3924-3931 | |||
| 59 | 2004 | One site mutation disrupts dimer formation in human DPP-IV proteins | Chien, CH; Huang, LH; Chou, CY; Chen, YS; Han, YS; Chang, GG; Liang, PH ; Chen, X | J Biol Chem 279, 52338-52345 | |||
| 60 | 2009 | Parallel gene cloning and protein production in multiple expression systems | Wang, HM; Shih, YP; Hu, SM; Lo, WT; Lin, HM; Ding, SS; Liao, HC; Liang, PH | Biotechnology Progress 25(6), 1582-6 | |||
| 61 | 2007 | Pharmacophores and biological activities of severe respiratory syndrome viral protease inhibitors | Wang, HM; Liang, PH | Expert Opinion on Therapeutic Patents 17, 533-546 | |||
| 62 | 2010 | Picornaviral 3C protease inhibitors and the dual 3C protease/coronaviral 3C-like protease inhibitors. | Wang, HM; Liang, PH | Expert opinion on therapeutic patents 20(1), 59-71 | |||
| 63 | 2000 | Potent and selective nonpeptide inhibitors of caspases 3 and 7 inhibit apoptosis and maintain cell functionality | Lee, D; Long, SA; Adams, JL; Chan, G; Vaidya, KS; Francis, TA; Kikly, K; Winkler, JD; Sung, CM; Debouck, C; Richardson, S; Levy, MA; DeWolf, WE; Keller, PM; Tomaszek, T; Head, MS; Ryan, MD; Haltiwanger, RC; Liang, PH ; Janson, CA; McDevitt, PJ; Johanson, K; Concha, NO; Chan, W; Abdel-Meguid, SS; Badger, AM; Lark, MW; Nadeau, DP; Suva, LJ; Gowen, M; Nuttall, ME | J Biol Chem 275, 16007-16014 | |||
| 64 | 1997 | Pre-Steady-State Kinetic Analysis of the Trichodiene Synthase Reaction Pathway | Cane, DE; Chiu, HT; Liang, PH ; Anderson, KS | Biochemistry 36, 8332-8339 | |||
| 65 | 2003 | Preliminary X-ray diffraction analysis of octaprenyl pyrophosphate synthase crystals from Thermotoga maritima and Escherichia coli. | Guo, RT; Ko, TP; Chou, CC; Shr, HL; Chu, HM; Tsai, YH; Liang, PH ; Wang, AHJ | ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY D59, 2265-2268 | |||
| 66 | 2003 | Probing electrostatic channeling in protozoal bifunctional thymidylate synthase-dihydrofolate reductase using site-directed mutagenesis | Atreya, CE; Johnson, EF; Williamson, J; Chang, SY; Liang, PH ; Anderson, KS | J Biol Chem 278, 28901-28911 | |||
| 67 | 2002 | Probing the Conformational Change of Escherichia coliUndecaprenyl Pyrophosphate Synthase during Catalysis Using an Inhibitor and Tryptophan Mutants | Chen, YH; Chen, AP; Chen, CT; Wang, AHJ ; Liang, PH | The Journal of biological chemistry 277(9), 7369-76 | |||
| 68 | 2001 | Processing of DNase domain during translocation of colicin E7 across the membrane of Escherichia coli | Liao, CC; Hsiao, KC; Liu, YW; Leng, PH ; Yuen, HS ; Chak, KF | Biochemical and Biophysical Research Communications 284(3), 556-562 | |||
| 69 | 2000 | Product distribution and pre-steady-state kinetic analysis of Escherichia coli undecaprenyl pyrophosphate synthase reaction | Pan, JJ; Chiou, ST; Liang, PH | Biochemistry 39, 10936-10942 | |||
| 70 | 2004 | Purification and characterization of human prolyl dipeptidase DPP8 in Sf9 insect cells | Chen, YS; Chien, CH; Goparaju, CM; Hsu, JT; Liang, PH ; Chen, X | Protein Expr Purif 35, 142-146 | |||
| 71 | 2000 | Raman difference spectroscopic studies of dithiobenzoyl substrate and product analogs binding to the enzyme dehalogenase:ppi-electron polarization is prevented by the C=O to C=S substitution. | Dong, J; Luo, LS; Liang, PH ; Dunaway-Mariano, D; Carey, PR | JOURNAL OF RAMAN SPECTROSCOPY 31, 365-371 | |||
| 72 | 2002 | Reaction kinetic pathway of the recombinant octaprenyl pyrophosphate synthase from Thermotoga maritima: how is it different from that of the mesophilic enzyme | Kuo, TH; Liang, PH | Biochimica et Biophysica Acta-Proteins and Proteomics 1599, 125-133 | |||
| 73 | 2009 | Reaction kinetics, catalytic mechanisms, conformational changes, and inhibitor design for prenyltransferases | Liang, PH | Biochemistry 48, 6562-6570 | |||
| 74 | 2011 | Recent development of 3C and 3CL protease inhibitors for anti-coronavirus and anti-picornavirus drug discovery | Ramajayam, R; Tan, KP; Liang, PH | BIOCHEMICAL SOCIETY TRANSACTIONS 39(5), 1371-1375 | |||
| 75 | 2001 | Refolding and characterization of a yeast dehydrodolichyl diphosphate synthase overexpressed in Escherichia coli | Chang, SY; Tsai, PC; Tseng, CS; Liang, PH | Protein Expr Purif 23, 432-439 | |||
| 76 | 2011 | Repression of btuB gene transcription in Escherichia coli by the GadX protein | Lei, GS; Syu, WJ; Liang, PH ; Chak, KF; Hu, WS; Hu, ST | BMC MICROBIOLOGY 11(1), 33 | |||
| 77 | 2012 | Roles of Amino Acids in the Escherichia coli Octaprenyl Diphosphate Synthase Active Site Probed by Structure-Guided Site-Directed Mutagenesis. | Chang, KM; Chen, SH; Kuo, CJ; Chang, CK; Guo, RT; Yang, JM; Liang, PH | BIOCHEMISTRY 51(6), 3412-3419 | |||
| 78 | 2021 | Simeprevir Potently Suppresses SARS-CoV-2 Replication and Synergizes with Remdesivir | Lo, HS; Hui, KPY; Lai, HM; He, X; Khan, KS; Kaur, S; Huang, J; Li, Z; Chan, AKN; Cheung, HH; Ng, KC; Ho, JCW; Chen, YW; Ma, B; Cheung, PM; Shin, D; Wang, K; Lee, MH; Selisko, B; Eydoux, C; Guillemot, JC; Canard, B; Wu, KP ; Liang, PH ; Dikic, I; Zuo, Z; Chan, FKL; Hui, DSC; Mok, VCT; Wong, KB; Mok, CKP; Ko, H; Aik, WS; Chan, MCW; Ng, WL | ACS central science 7(5), 792-802 | |||
| 79 | 1998 | Site-Directed Mutagenesis Probing the Catalytic Role of Arginines 165 and 166 of Human Cytomegalovirus Protease | Liang, PH ; Brun, KA; Feild, JA; O’Donnell, K; Doyle, ML; Green, SM; Baker, AE; Blackburn, MN; Abdel-Meguid, SS | Biochemistry 37, 5923-5929 | |||
| 80 | 2004 | Small molecules targeting severe acute respiratory syndrome human coronavirus | Wu, C. Y.; Jan, J. T. ; Ma, S. H.; Kuo, C. J.; Juan, H. F.; Cheng, Y. S.; Hsu, H. H.; Huang, H. C.; Wu, D.; Brik, A.; Liang, F. S.; Liu, R. S.; Fang, J. M.; Chen, S. T. ; Liang, P. H. ; Wong, C. H. | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 101(27), 10012-10017 | |||
| 81 | 2007 | Specific plant terpenoids and lignoids possess potent antiviral activities against severe acute respiratory syndrome coronavirus | Wen, CC; Kuo, YH; Jan, JT; Liang, PH ; Wang, SY; Liu, HG; Lee, CK; Chang, ST; Kuo, CJ; Lee, SS; Hou, CC ; Hsiao, PW ; Chien, SC; Shyur, LF ; Yang, NS | Journal of Medicinal Chemistry 50(17), 4087-4095 | |||
| 82 | 1993 | Specificity of 4-chlorobenzoate-Coenzyme A dehalogenase catalyzed dehalogenation of halogenated aromatics | Liang, PH ; Yang, G; Dunaway-Mariano, D | Biochemistry 32, 12245-12250 | |||
| 83 | 2006 | Stable benzotriazole esters as mechanism-based inhibitors of the severe acute respiratory syndrome 3CL protease | Wu, CY; King, KY; Kuo, CJ; Fang, JM; Wu, YT; Ho, MY; Liao, CL; Shie, JJ; Liang, PH ; Wong, CH | Chem Biol 13, 261-268 | |||
| 84 | 2001 | Steady-state kinetic characterization of substrates and metal-ion specificities of the full-length and N-terminally truncated recombinant human methionine aminopeptidases (type 2) | Yang, G; Kirkpatrick, RB; Ho, T; Zhang, GF; Liang, PH ; Johanson, KO; Casper, DJ; Doyle, ML; Marino, JP; Thompson, SK; Chen, W; Tew, DG; Meek, TD | Biochemistry 40, 10645-10654 | |||
| 85 | 2011 | Structural and functional analysis of three β-glucosidases from bacterium Clostridium cellulovorans, fungus Trichoderma reesei and termite Neotermes koshunensis | Jeng, WY; Wang, NC; Lin, MH; Lin, CT; Liaw, YC ; Chang, WJ; Liu, CI; Liang, PH ; Wang, AHJ | Journal of structural biology 173(1), 46-56 | |||
| 86 | 2009 | Structural basis of inhibition specificities of 3C and 3C-like proteases by zinc-coordinating and peptidomimetic compounds. | Lee, CC; Kuo, CJ; Ko, TP; Hsu, MF; Tsui, YC; Chang, SC; Yang, S; Chen, SJ; Chen, HC; Hsu, MC; Shih, SR; Liang, PH ; Wang, AH | The Journal of biological chemistry 284(12), 7646-7655 | |||
| 87 | 2007 | Structural basis of mercury- and zinc-conjugated complexes as SARS-CoV 3C-like protease inhibitors. | Lee, CC; Kuo, CJ; Hsu, MF; Liang, PH ; Fang, JM; Shie, JJ; Wang, AHJ | FEBS letters 581(28), 5454-5458 | |||
| 88 | 2010 | Structure of a Heterotetrameric Geranyl Pyrophosphate Synthase from Mint (Mentha piperita) Reveals Intersubunit Regulation. | Chang, TH; Hsieh, FL; Ko, TP; Teng, KH; Liang, PH ; Wang, AHJ | The Plant Cell 22(2), 454-467 | |||
| 89 | 2012 | Structure of the catalytic domain of the Clostridium thermocellum cellulase CelT | Kesavulu, MM; Tsai, JY; Lee, HL; Liang, PH ; Hsiao, CD | Acta Crystallographica Section D: Biological Crystallography D68, 310-320 | |||
| 90 | 2002 | Structure, mechanism and function of prenyltransferases. | Liang, PH ; Ko, TP; Wang, AHJ | EUROPEAN JOURNAL OF BIOCHEMISTRY 269(14), 3339-3354 | |||
| 91 | 2007 | Structure-Based Design and Synthesis of Highly Potent SARS-CoV 3CL Protease Inhibitors | Shao, Y. M.; Yang, W. B. ; Peng, H. P.; Hsu, M. F.; Tsai, K. C.; Kuo, T. H.; Wang, A. H. J. ; Liang, P. H. ; Lin, C. H. ; Yang, A. S. ; Wong, C. H. | ChemBioChem 8(14), 1654-1657 | |||
| 92 | 2006 | Structure-Based Drug Design and Structural Biology Study of Novel Nonpeptide Inhibitors of SARS-CoV Main Protease | Lu, IL; Mahindroo, N; Liang, PH ; Peng, YH; Kuo, CJ; Tsai, KC; Hsieh, HP; Chao, YS; Wu, SY | J Med Chem 49, 5154-5161 | |||
| 93 | 2008 | Structure-based inhibitors exhibit differential activities against Helicobacter pylori and Escherichia coli undecaprenyl pyrophosphate synthases | Kuo, CJ; Guo, RT; Lu, IL; Liu, HG; Wu, SY; Ko, TP; Wang, AHJ ; Liang, PH | Journal of biomedicine & biotechnolog 2008, 841312 | |||
| 94 | 2012 | Structures, mechanisms and inhibitors of undecaprenyl diphosphate synthase: A cis-prenyltransferase for bacterial peptidoglycan biosynthesis | Teng, KH; Liang, PH | BIOORGANIC CHEMISTRY 43, 51-57 | |||
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