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  1. Scholars Hub of the Academia Sinica
Academia Sinica / Division of Life Sciences / Agricultural Biotechnology Research Center

Shyur, Lie-Fen

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  • 6 chen, c. -s.
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Results 1-112 of 112 (Search time: 0.001 seconds).

Issue DateTitleAuthor(s)RelationscopusWOSFulltext/Archive link
12007A galactolipid possesses novel cancer chemopreventive effects by suppressing inflammatory mediators and mouse B16 melanomaHou, C. -C. ; Chen, Y. -P.; Wu, J. -H.; Huang, C. -C.; Wang, S. -Y.; Yang, N. -S.; Shyur, L. -F. CANCER RESEARCH 67,  6907-6915
22016A novel plant sesquiterpene lactone derivative DETD-35 suppresses BRAFV600E mutant melanoma growth and overcomes acquired vemurafenib resistance in miceJia-Hua Feng; Kyoko Nakagawa-Goto; Kuo-Hsiung Lee; Lie-Fen Shyur MOLECULAR CANCER THERAPEUTICS 15(6), 1163-1176
32007A novel polyacetylene significantly inhibits angiogenesis and promotes apoptosis in human endothelial cells through activation of the CDK inhibitors and caspase-7Wu, L. -W.; Chiang, Y. -M.; Chuang, H. -C.; Lo, C. -P.; Yang, K. -Y.; Wang, S. -Y.; Shyur, L. -F. Planta Medica  73, 655-661.
42011A sesquiterpenol extract potently suppresses inflammation in macrophages and mice skin and prevents chronic liver damage in mice through JNK-dependent HO-1 expressionShyur, L. -F. ; Huang, C. -C.; Hsu, Y. -Y.; Cheng, Y. -W.; Yang, S. -D.Phytochemistry 72(4-5), 391-399
51996A study of subunit interface residues of fructose-1,6-bisphosphatase by site-directed mutagenesis: effect on AMP and Mg2+ affinityShyur, L. -F. ; Aleshin, A. E.; Fromm, H. J.Biochemistry 35, 7492-7498
62005A truncated Fibrobacter succinogenes 1,3-1,4-beta-d-glucanase with improved enzymatic activity and thermotoleranceWen, T. N. ; Chen, J. L.; Lee, S. H.; Yang, N. S. ; Shyur, L. F. Biochemistry 44(25), 9197-9205
72001Antioxidant Activity of Abietane-Type Diterpenes from Heartwood of Taiwania cryptomerioides HayataWang, S. Y.; Wu, J. H.; Shyur, L. F. ; Kuo, Y. H.; Chang, S. T.HOLZFORSCHUNG 56,  487-492
82001Antioxidant activity of extracts from Acacia confusa bark and heartwoodChang, S. T.; Wu, J. H.; Wang, S. Y.; Kang, P. L.; Yang, N. S. ; Shyur, L. F. Journal of Agricultural and Food Chemistry 49(7), 3420-3424
92004Antioxidant Activity of Extracts from Calocedrus formosana Leaf, Bark and HeartwoodWang, S. Y.; Wu, J. H.; Cheng, S. S.; Lo, C. P.; Chang, H. N.; Yang, N. S.; Shyur, L. F. ; Chang, S. T.JOURNAL OF WOOD SCIENCE 50,  422-426
102003Antioxidant properties and phytochemical characteristics of extracts from Lactuca indicaWang, S. Y.; Chang, H. N.; Lin, K. T.; Lo, C. P.; Yang, N. S.; Shyur, L. F. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 51,  1506-1512
112020Association of Arachidonic Acid-derived Lipid Mediators with Subsequent Onset of Acute Myocardial Infarction in Patients with Coronary Artery DiseaseHuang, C.-C.; Chang, M.-T.; Leu, H.-B.; Yin, W.-H.; Tseng, W.-K.; Wu, Y.-W.; Lin, T.-H.; Yeh, H.-I; Chang, K.-C.; Wang, J.-H.; Wu, C.-C.; Shyur, L.-F. ; Chen, J.-W.SCIENTIFIC REPORTS 10, 8105
122012Biochemical characterization of a novel laccase from the basidiomycete fungus Cerrena sp. WR1.Chen, S. -C.; Wu, P. -H.; Su, Y. -C.; Wen, T. -N.; Wei, Y. -S.; Wang, N. -C.; Hsu, N. -C.; Wang, Andrew H. -J.; Shyur, L. -F. Protein Engineering Design & Selection 25, 761-769.
131996Biochemical properties of mutant and wild-type fructose-1,6-bisphosphatase are consistent with the coupling of intra- and inter-subunit conformational changes in the T- and R-state transitionShyur, L. -F. ; Aleshin, A. E.; Honzatko, R. B.; Fromm, H. J.Journal of Biological Chemistry 271, 33301-33307
142012Biological degradation of anthroquinone and azo dyes by a novel laccase from Lentinus sp.Hsu, C. -A.; Wen, T. -N.; Su, Y. -C.; Jiang, Z. -B.; Chen, C. -W.; Shyur, L. -F. Environmental Science and Technology 46, 5109-5117
152009Cancer and inflammatory disorder treatmentShyur, L. -F. ; Hou, C. -C.; Wu, J. -H.; Chen, Y. -P.; Wang, S. -Y.; Huang, C. -C.; Yang, N. -S.S patent issued No. 7547455 and ROC patents pending No. 7547455
161992cDNA cloning and gene expression of the major prolamins of riceShyur, L. -F. ; Wen, T. -N.; Chen, C. -S.Plant Mol. Biol. 20,323-326
172022Cellular and Molecular Signaling as Targets for Cancer Vaccine TherapeuticsWei, Wen-Chi; Shyur, Lie-Fen ; Yang, Ning-Sun Cells 11(9), 1590
182005Chemical composition and antifungal activity of essential oil isolated from Chamaecyparis formosensis Matsum. WoodWang, S. Y.; Wu, C. L.; Chu, F. H.; Chien, S. C.; Kuo, Y. H.; Shyur, L. F. ; Chang, S. T.HOLZFORSCHUNG 59(3), 295-299
192010Comparative metabolomics approach coupled with cell- and gene-based assays for species classification and anti-inflammatory bioactivity validation of Echinacea plantsHou, C. C. ; Chen, C. H. ; Yang, N. S. ; Chen, Y. P.; Lo, C. P.; Wang, S. Y.; Tien, Y. J.; Tsai, P. W.; Shyur, L. F. Journal of Nutritional Biochemistry 21(11), 1045-1059
201996Complete structures of three rice sucrose synthase isogenes and differential regulation of their expressionsHuang, J. -W.; Chen, J. -Y.; Yu, W. -P.; Shyur, L. -F. ; Wang, A. -Y.; Sung, H. -Y.; Lee, P. -D.; Su, J. -C.Bioscience Biotechnology and Biochemistry 60(2), 233-239
212016Copper supplementation amplifies the anti-tumor effect of curcumin in oral cancer cells.Lee, H.-M.; Patela, V.; Shyur, L.-F. ; Lee, W. L.Phytomedicine 23(12), 1535-1544
222003Crystal Structure of a Natural Circularly Permuted Jellyroll Protein: 1,3-1,4-β-d-Glucanase from Fibrobacter succinogenesTsai, L. C.; Shyur, L. F. ; Lee, S. H.; Lin, S. S.; Yuan, H. S. Journal of Molecular Biology 330(3), 607-620
232005Crystal structure of truncated Fibrobacter succinogenes 1,3-1,4-β-d-glucanase in complex with β-1,3-1,4-cellotrioseTsai, L. -C.; Shyur, L. -F. ; Cheng, Y. -S.; Lee, S. -H.Journal of Molecular Biology 354(3), 642-651
242011Crystal Structures of the Laminarinase Catalytic Domain from Thermotoga maritima MSB8 in Complex with Inhibitors: ESSENTIAL RESIDUES FOR β-1,3- and β-1,4-GLUCAN SELECTIONJeng, WY; Wang, NC; Lin, CT; Shyur, LF ; Wang, AHJ Journal of biological chemistry 286(52), 45030-45040
252001Crystallization and preliminary X-ray diffraction analysis of the 1,3-1,4-β-D-glucanase from Fibrobacter succinogenesTsai, L. C.; Shyur, L. F. ; Lin, S. S.; Yuan, H. S. Acta Crystallographica Section D-Biological Crystallography D57, 1303-1306
262019Cumingianoside A, a Phyto-Triterpenoid Saponin Inhibits Acquired BRAF Inhibitor Resistant Melanoma Growth via Programmed Cell DeathCvetanova, B.; Shen, Y.-C.; Shyur, L.-F. Frontiers in Pharmacology 10, 30
272021Current Advancements of Plant-Derived Agents for Triple-Negative Breast Cancer Therapy through Deregulating Cancer Cell Functions and Reprogramming Tumor MicroenvironmentTai-Na Wu ; Hui-Ming Chen ; Lie-Fen Shyur International Journal of Molecular Sciences 22(24), 13571
282010Current research and development of chemotherapeutic agents for melanoma    Hsan, K. M.; Chen, C. -C.; Shyur, L. -F. Cancers 2, 397-419
292012Deoxyelephantopin impedes mammary adenocarcinoma cell motility through inhibiting calpain-mediated adhesion dynamics and inducing ROS and aggresome formation.Lee, W. -L.; Shyur, L. -F. Free Radical Biology & Medicine 52, 1423-1436
302012Deoxyelephantopin protects mice from lipopolysaccharide/D-galactosamine-induced fulminant hepatitis through attenuating LPS, TNF-α, or IL-6 mediated signaling pathways.Huang, C. -C.; Lin, K. -J.; Cheng, Y. -W.; Hsu, C. -A.; Yang, S. -S.; Shyur, L. -F. Journal of Nutritional Biochemistry (doi:10.1016/j.jnutbio.2012.01.013).
312010Deoxyelephantopin, a novel multifunctional agent suppresses mammary tumor growth and lung metastasis and doubles survival time in miceHuang, C. -C.; Lo, C. -P.; Chiu, C. -Y.; Shyur, L. -F. British Journal of Pharmacology 159, 856-871
322020Deregulating the CYP2C19/Epoxy-Eicosatrienoic Acid-Associated FABP4/FABP5 Signaling Network as a Therapeutic Approach for Metastatic Triple-Negative Breast CancerMaria Karmella Apaya; Pei-Wen Hsiao ; Yu-Chih Yang; Lie-Fen Shyur CANCERS 12(1), 199
332010Differential proteomic profiling identifies novel molecular targets of paclitaxel and phytoagent deoxyelephantopin against mammary adenocarcinoma cellsLee, Wai-Leng; Wen, Tuan-Nan; Shiau, Jeng-Yuan; Shyur, Lie-Fen Journal of Proteome Research 9(1), 237-253.
342011Dioscorea Phytocompounds Enhance Murine Splenocyte Proliferation Ex Vivo and Improve Regeneration of Bone Marrow Cells In VivoSu, PF; Li, CJ; Hsu, CC; Benson, S; Wang, SY; Chan, SI; Wu, SH ; Huang, WC; Shyur, LF ; Yang, NS Evidence-based Complementary and Alternative Medicine 2011, 731308
352001Directed Mutagenesis of Specific Active Site Residues onFibrobacter succinogenes1,3–1,4-β-d-Glucanase Significantly Affects Catalysis and Enzyme Structural StabilityChen, JL; Tsai, LC; Wen, TN ; Tang, JB; Yuan, HS ; Shyur, LF Journal of Biological Chemistry 276(21), 17895-17901
362018Dual specificity phosphatase DUSP6 promotes endothelial inflammation through inducible expression of ICAM-1Hsu, S.-F.; Lee, Y.-B.; Lee, Y.-C.; Chung, A.-L.; Apaya, K. M.; Shyur, L.-F. ; Cheng, C.-F.; Ho, F.-M.; Meng, T.-C.The FEBS Journal 285(9), 1593-1610
372011Echinacea alkamides prevent lipopolysaccharide/D-galactosamineinduced acute hepatic injury through JNK pathway-mediated HO-1 expressionHou, C. -C.; Huang, C. -C.; Shyur, L. -F. Journal of Agricultural and Food Chemistry 59, 11966-11974
382008Effect of phytocompounds from the heartwood of Acacia confusa on inflammatory mediator productionWu, J. -H.; Tung, Y. -T.; Chien, S. -C.; Wang, S. -Y.; Kuo, Y. -H.; Shyur, L. -F. ; Chang, S. -T.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 56, 1567-1573
392007Effects of Chamaecyparis formosensis Matasumura extractives on lipopolysaccharide-induced release of nitric oxideHsieh, Y. -H.; Kuo, P. -M.; Chien, S. -C.; Shyur, L. -F. ; Wang, S. -Y.PHYTOMEDICINE 14,  675-680
402021Elucidation of enzymes involved in the biosynthetic pathway of bioactive polyacetylenes in Bidens pilosa using integrated omics approachesChung, H.-H.; Ting, H.-M.; Wang, W.-H.; Chao, Y.-T.; Hsieh, C.-H.; Apaya, M. K.; Sung, Y.-C.; Lin, S.-S.; Hwu, F.-Y.; Shyur, L.-F. Journal of Experimental Botany 72(2), 525-541
412012Engineering of dual functional hybrid glucanasesLiu, W. -C.; Lin, Y. -S.; Jeng, W. -Y.; Chen, J. -H.; Wang, A. H. -J.; Shyur, L. -F. Protein Engineering Design & Selection 25, 771-780.
422019Essential oil of Mentha aquatica var. Kenting Water Mint suppresses two-stage skin carcinogenesis accelerated by BRAF inhibitor vemurafenib.Chang, C.-T.; Soo, W.-N.; Chen, Y.-H.; Shyur, L.-F. Molecules 24(12), 2344
432005Ethyl caffeate suppresses NF-κB activation and its downstream inflammatory mediators, iNOS, COX-2, and PGE2in vitro or in mouse skinChiang, Y. -M.; Lo, C. -P.; Chen, Y. -P.; Wang, S. -Y.; Yang, N. -S. ; Kuo, Y. -H.; Shyur, L. -F. British Journal of Pharmacology 146(3), 352-363
442021Extract of white sweet potato tuber against TNF-α-induced insulin resistance by activating the PI3K/Akt pathway in C2C12 myotubesShyur, L.-F. ; Varga, V.; Chen, C.-M.; Mu, S.-C.; Chang, Y.-C.; Li, S.-C.BOTANICAL STUDIES 62,, 7
452007Flavonoids, centaurein and centaureidin, from Bidens pilosa, stimulate IFN-γ expressionChang, S. L.; Chiang, Y. M.; Chang, C. L. T.; Yeh, H. H.; Shyur, L. F. ; Kuo, Y. H.; Wu, T. K.; Yang, W. C. JOURNAL OF ETHNOPHARMACOLOGY 112, 232-236
462008Genomics and proteomics of immune modulatory effects of a butanol fraction of Echinacea purpurea in human dendritic cellsWang, C. -Y.; Staniforth, V.; Chiao, M. -T.; Hou, C. -C. ; Wu, H. -M.; Yeh, K. -C.; Chen, C. -H. ; Hwang, P. -I.; Wen, T. -N. ; Shyur, L. -F. BMC Genomics 9, 479-498
472024Glutathione S-transferase omega class 1 (GSTO1)-associated large extracellular vesicles are involved in tumor-associated macrophage-mediated cisplatin resistance in bladder cancerYi-Cheng Pan; Pei-Yi Chu; Ching-Chan Lin; Ching-Yun Hsieh; Wei-Yu Hsu; Lie-Fen Shyur ; Juan-Cheng Yang; Wei-Chao Chang; Yang-Chang WuMolecular Oncology 18(8), 1866-1884
482008Hepatoprotective phytocompounds from Cryptomeria japonica are potent modulators of inflammatory mediatorsShyur, L. -F. ; Huang, C. -C.; Lo, C. -P.; Chiu, C. -Y.; Chen, Y. -P.; Wang, S. -Y.; Chang, S. -T.PHYTOCHEMISTRY 69,  1348-1358
492022Identification of Serum Oxylipins Associated with the Development of Coronary Artery Disease: A Nested Case-Control StudyChiang, Kuang-Mao; Chen, Jia-Fu; Yang, Chin-An; Xiu, Lili; Yang, Hsin-Chou ; Shyur, Lie-Fen ; Pan, Wen-Harn Metabolites 12(6), 495
502008Immunomodulatory effects of phytocompounds characterized by in vivo transgenic human GM-CSF promoter activity in skin tissuesSu, P. -F.; Staniforth, V.; Li, Ch. -J.; Wang, C. -Y.; Chiao, M. -T.; Wang, S. -Y.; Shyur, L. -F. ; Yang, N. -S.Journal of Biomedical Science 15(6), 813-22
512008Immunomodulatory phytocompounds and the highly efficient platform to screen the sameYang, W. -C.; Chang, S. -L.; Chiang, Y. -M.; Shyur, L. -F. US patent pending  
522004Induction of apoptosis in MCF-7 human breast cancer cells by phytochemicals from Anoectochilus formosanusShyur, L. -F. ; Chen, C. -H.; Lo, C. -P.; Wang, S. -Y.; Kung, P. -L.; Sun, S. -J.; Chang, C. Allen; Tzeng, C. -M.; Yang, N. -S. Journal of Biomedical Science 11(6), 928-939
532019Integrated omics-based pathway analyses uncover CYP epoxygenase-associated networks as theranostic targets for metastatic triple negative breast cancerApaya, Maria Karmella; Shiau, Jeng-Yuan; Liao, Guo-Shiou; Liang, Yu-Jen; Chen, Chia-Wei; Yang, Hsin-Chou ; Chu, Chi-Hong; Yu, Jyh-Cherng; Shyur, Lie-Fen Journal of Experimental & Clinical Cancer Research 38, 187
541997Major changes in the kinetic mechanism of AMP inhibition and AMP cooperativity attend the mutation of Arg49 in fructose-1,6-bisphosphataseShyur, L. F. ; Pollan, B.; Honzatko, R. B.; Fromm, H. J.JOURNAL OF BIOLOGICAL CHEMISTRY 272,  26295-26299
552015Mammalian target of rapamycin complex 2 (mTORC2) regulates LPS-induced expression of IL-12 and IL-23 in human dendritic cellsWen-Chi Wei; Chih-Pin Liu; Wen-Chin Yang ; Lie-Fen Shyur ; Jyh-Horng Sheu; Swey-Shen Chen; Ning-Sun Yang Journal of Leukocyte Biology 97(6), 1071-1080
562015Mechanistic Study of the Phytocompound, 2-β-D-Glucopyranosyloxy-1-hydroxytrideca-5,7,9,11-tetrayne in Human T-Cell Acute Lymphocytic Leukemia Cells by Using Combined Differential Proteomics and Bioinformatics ApproachesShiau, J.-Y.; Yin, S.-Y.; Chang, S.-L.; Hsu, Y.-J.; Chen, K.-W.; Kuo, T.-F.; Feng, C.-S.; Yang, N.-S. ; Shyur, L.-F. ; Yang, W.-C. ; Wen, T.-N. Evidence-Based Complementary and Alternative Medicine 2015, 475610
572004Medicinal herb extract and a single-compound drug confer similar complex pharmacogenomic activities in MCF-7 cellsYang, NS ; Shyur, LF ; Chen, CH; Wang, SY; Tzeng, CMJournal of Biomedical Science 11(3), 418-422
582004Metabolite Profiling and Chemopreventive Bioactivity of Plant Extracts from Bidens pilosaChiang, Y. M.; Chuang, D. Y.; Wang, S. Y.; Kuo, Y. H.; Tsai, P. W.; Shyur, L. F. Journal of Ethnopharmacology 95(2-3), 409-419
592017Metabolomic compounds identified in Piriformospora indica-colonized Chinese cabbage roots delineate symbiotic functions of the interactionHua, M. D.; Senthil Kumar, R.; Shyur, L.-F. ; Cheng, Y.-B.; Tian, Z.; Oelmüller, R.; Yeh, K.-W.Scientific Reports 7, 9291
602008Metabolomics for phytomedicine research and drug developmentShyur, L. -F. ; Yang, N. -S.CURRENT OPINION IN CHEMICAL BIOLOGY 12,  66-71
612008Methods for enhancing proliferation of bone marrow cells or spleen cells with an ethanol-insoluble extract of DioscoreaYang, N. -S.; Su, P. -F.; Li, C. -J.; Shyur, L. -F. (US patent issued No: 7,419,690 B2; ROC patent pending) (One technology licensing/transfer to local biotech company) No: 7,419,690 B2
622023MicroRNA-Mediated Mitochondrial Dysfunction Is Involved in the Anti-triple-Negative Breast Cancer Cell Activity of Phytosesquiterpene LactonesCheng, Yu-Ting; Nakagawa-Goto, Kyoko; Lee, Kuo-Hsiung; Shyur, Lie-Fen ANTIOXIDANTS & REDOX SIGNALING 38(1-3), 198-214
632008Mutational and structural studies of the active-site residues in truncated Fibrobacter succinogenes 1,3–1,4-β-D-glucanaseTsai, L. -C.; Huang, H. -C.; Hsiao, C. -H.; Chiang, Y. -N.; Shyur, L. -F. ; Lin, Y. -S.; Lee, S. -H.ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY D64, 1259–1266
642015New alkaloids from Formosan zoanthid Zoanthus kuroshioCheng, Y.-B.; Lo, I-W.; Shyur, L.-F. ; Yang, C.-C.; Hsu, Y.-Mi.; Su, J.-H.; Lu, M.-C.; Chiou, S.-F.; Lan, C.-C.; Wu, Y.-C.; Chang, F.-R.Tetrahedron 71, 8601-8606
652016Novel effect and the mechanistic insights of fruiting body extract of medicinal fungus Antrodia cinnamomea against T47D breast cancer.Shang, K.-M.; Su, T.-H.; Lee, W. L.; Hsiao, W.-W.; Chiou, C.-Y.; Ho, B.-Y.; Wang, S.-Y.; Shyur, L.-F. Phytomedicine 24, 39-48
662016Novel sesquiterpene lactone analogues as potent anti-breast cancer agentsNakagawa-Goto, K.; Chen, J.-Y.; Cheng, Y.-T.; Lee, W.-L.; Takeya, M.; Saito, Y.; Lee, K.-H.; Shyur, L.-F. Molecular Oncology 10(6), 921-937
671993Nucleotide sequence of a rice prolamin storage protein gene, RP6Wen, T. -N.; Shyur, L. -F. ; Chen, C. -S.Plant Physiology 101,1115-1116
681990Nucleotide sequence of two rice prolamin cDNAsShyur, L. -F. ; Chen, C. -S.Nucleic Acids Research 18, 6683
692005Phenolic Antioxidants From the Heartwood of Acacia confusaWu, J. -H.; Tung, Y. -T.; Wang, S. -Y.; Shyur, L. -F. ; Kuo, Y. -H.; Chang, S. -T.Journal of Agricultural and Food Chemistry 53(15), 5917-5921
702019Phyto-sesquiterpene lactone deoxyelephantopin and cisplatin synergistically suppress lung metastasis of B16 melanoma in mice with reduced nephrotoxicityWen-Wan Chao; Ya-Wen Cheng; Yet-Ran Chen ; Shu-Hua Lee; Ching-Yi Chiou; Lie-Fen Shyur Phytomedicine 56, 194-206
712022Phyto-sesquiterpene lactones DET and DETD-35 induce ferroptosis in vemurafenib sensitive and resistant melanoma via GPX4 inhibition and metabolic reprogrammingChang, Meng-Ting; Tsai, Li-Chu; Nakagawa-Goto, Kyoko; Lee, Kuo-Hsiung; Shyur, Lie-Fen Pharmacological Research 178, 106148
722024Phytocompounds from essential oil of Mentha aquatica L. cv. Lime prevent vemurafenib-promoted skin carcinogenesis via inhibiting HRASQ61L keratinocytes and reprogramming macrophage activitiesChang, Chih-Ting; Chen, Yu-Hsin; Shyur, Lie-Fen Phytomedicine 122, 155161
732021Phytogalactolipid dLGG inhibits mouse melanoma brain metastasis through regulating oxylipin activity and re-programming macrophage polarity in the tumor microenvironmentYang, C.-C.; Chang, M.-M.; Chang, C.-K.; Shyur, L.-F. Cancers 13(16), 4120
742023Phytogalactolipids activate humoral immunity against colorectal cancerLin, H.-H; Wu, Y.-S.; Jian, T-Y.; Laio, J.-Y.; Chang, M.-T.; Shyur, L.-F. ; Lin, Y.-L. Journal of Experimental & Clinical Cancer Research 42, 95
752016Phytomedicine polypharmacology: Cancer therapy through modulating the tumor microenvironment and oxylipin dynamicsMaria Karmella Apaya; Meng-Ting Chang; Lie-Fen Shyur Pharmacology and Therapeutics 162, 58-68
762016Phytomedicine-Modulating oxidative stress and the tumor microenvironment for cancer therapyCheng, Y.-T.; Yang, C.-C.; Shyur, L.-F. Pharmacological Research 114, 128-143
772018Plant galactolipid dLGG suppresses lung metastasis of melanoma through deregulating TNF-α-mediated pulmonary vascular permeability and circulating oxylipin dynamics in miceYang, C.-C.; Chang, C.-K.; Chang, M.-T.; Shyur, L.-F. International Journal of Cancer 143(12), 3248-3261
782024Plant-derived galactolipids enhance specific antibody production and induce class-switch as vaccine adjuvantLin, HH; YS, Wu; Chang, MT; Shyur, LF ; Lin, YL VACCINE 42(4), 782-794
792004Polyacetylenes function as anti-angiogenic agentsWu, L. -W.; Chiang, Y. -M.; Chuang, H. -C.; Wang, S. -Y.; Yang, G. -W.; Chen, Y. -H.; Lai, L. -Y.; Shyur, L. -F. PHARMACOLOGICAL RESEARCH 21, 2112-2119
802004Polyacetylenic compounds and butanol fraction from Bidens pilosa can modulate the differentiation of helper T cells and prevent autoimmune diabetes in non-obese diabetic miceChang, S. L.; Chang, C. L. T.; Chiang, Y. M.; Hsieh, R. H.; Tzeng, C. R.; Wu, T. K.; Sytwu, H. K.; Yang, N. S.; Shyur, L. F. ; Yang, W. C.PLANTA MEDICA 70, 1045-1051
812002Profiling and Characterization Antioxidant Activities in Anoectochilus formosanus HayataWang, SY; Kuo, YH; Chang, HN; Tsay, HS; Lin, KF; Yang, NS ; Shyur, LF Journal of Agricultural and Food Chemistry 50(7), 1859-1865
822015Pu-erh tea polysaccharides decrease blood sugar by inhibition alpha-glucosidase activities in vitro and in mice.Deng, Y.-T.; Lin-Shiau, S.-Y.; Shyur, L.-F. ; Lin, J.-K.Food & Function 6(5), 1539-1546
832008Pure compounds (2-D-glucopyranosyloxy-1-hydroxytrideca-5,7,9,11-triyne and 3-D- glucopyranosyloxy-1-hydroxy-6(E)-tetradecene-8,10,12-triyne) and n-butanol fraction from Bidens pilosa Linn. var. radiate. can prevent Th1-mediated autoimmune disease via suppressing Th1 cell differentiation and/or promoting Th2 cell differentiationYang, W. -C.; Chang, S. -L.; Chang, L. -T.; Chiang, Y. -M.; Shyur, L. -F. US and ROC patents pending (One technology licensing/transfer to local biotech company)  
841994Purification and characterization of rice prolaminShyur, L. -F. ; Wen, T. -N.; Chen, C. -S.Botanical Bulletin of Academia Sinica 35, 65-71
851988Purification and some properties of storage proteins in japonica riceShyur, L. -F. ; Zia, K. -K.; Chen, C. -S.Botanical Bulletin of Academia Sinica 29, 113-122
862023Quantitative proteomic analysis of differential proteins in helichrysetin-treated human lung carcinoma cells, A549Yen Fong Ho; Noor Liana Mat Yajit; Jeng-Yuan Shiau; Sri Nurestri Abd Malek; Lie-Fen Shyur ; Saiful Anuar KarsaniApplied Biochemistry and Biotechnology
871993Rice prolamins: heterogeneity of cDNA and synthesis of precursorsShyur, L. -F. ; Chen, C. -S.Botanical Bulletin of Academia Sinica 34, 143-154
882021Sesquiterpene lactone deoxyelephantopin isolated from Elephantopus scaber and its derivative DETD-35 suppress BRAFV600E mutant melanoma lung metastasis in miceCvetanova, B.; Li, M.-Y.; Yang, C.-C.; Hsiao, P.-W. ; Yang, Y.-C.; Feng, J.-H.; Shen, Y.-C.; Nakagawa-Goto, K.; Lee, K.-H.; Shyur, L.-F. International Journal of Molecular Sciences 22(6), 3226
892004Shikonins, Phytocompounds from Lithospermum erythrorhizon, Inhibit the Transcriptional Activation of Human Tumor Necrosis Factor α Promoter in VivoStaniforth, V; Wang, SY; Shyur, LF ; Yang, NS Journal of Biological Chemistry 279(7), 5877-5885
902015Simvastatin and a plant galactolipid protect animals from septic shock by regulating oxylipin mediator dynamics through the MAPK-cPLA2 signaling pathwayApaya, M. K.; Lin, C.-Y.; Chiou, C.-Y.; Yang, C.-C.; Ting, C.-Y.; Shyur, L.-F. Molecular Medicine 21, 988-1001
911996Site-directed mutagenesis of residues at subunit interface of porcine fructose-1,6-bisphosphataseShyur, L. -F. ; Aleshin, A. E.; Honzatko, R. B.; Fromm, H. J.Journal of Biological Chemistry 271,3005-3010
921995Site-directed mutagenesis of  substrate binding site of porcine liver fructose-1,6-bisphosphataseShyur, L. -F. ; Zhang, R.; Fromm, H. J.Arch. Biochem. Biophys. 319,123-127
932007Specific plant terpenoids and lignoids possess potent antiviral activities against severe acute respiratory syndrome coronavirusWen, CC; Kuo, YH; Jan, JT; Liang, PH ; Wang, SY; Liu, HG; Lee, CK; Chang, ST; Kuo, CJ; Lee, SS; Hou, CC ; Hsiao, PW ; Chien, SC; Shyur, LF ; Yang, NS Journal of Medicinal Chemistry 50(17), 4087-4095
942010Structural and catalytic roles of amino acid residues located at substrate binding pocket in Fibrobacter succinogenes 1,3-1,4-beta-D-glucanaseChen, J. -H.; Tsai, L. -C.; Huang, H. -C.; Shyur, L. -F. PROTEINS: Structure, Function, and Bioinformatics 78, 2820-2830
952009Structural and catalytic roles of residues located in β13 strand and the following β-turn loop in Fibrobacter succinogenes 1,3-1,4-β-d-glucanaseLin, Y. -S.; Tsai, L. -C.; Lee, S. -H.; Yuan, H. S. ; Shyur, L. -F. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS 1790(4), 231-239
962015Structural and functional roles of glycosylation in fungal laccase from Lentinus sp.Liu, W.-C.; Maestre-Reyna, M.; Jeng, W.-Y.; Lee, C.-C.; Hsu, C.-A.; Wen, T.-N.; Wang, A. H.-J.; Shyur, L.-F. PLoS ONE 10(4), e0120601
972011Structural basis for the inhibition of 1,3-1,4-β-D-glucanase by noncompetitive calcium ion and competitive Tris inhibitorsTsai, L. -C.; Hsiao, C. -H.; Liu, W. -Y.; Yin, L. -M.; Shyur, L. -F. Biochemical and Biophysical Research Communication 407, 593-598
982008Structural modeling of glucanase–substrate complexes suggests a conserved tyrosine is involved in carbohydrate recognition in plant 1,3-1,4-β-D-glucanasesTsai, L. -C.; Chen, Y. -N.; Shyur, L. -F. Journal of Computer-Aided Molecular Design 22(12), 915-923
992010Taiwanin A inhibits MCF-7 cancer cell activity through induction of oxidative stress, upregulation of DNA damage checkpoint kinases, and activation of p53 and FasL/Fas signaling pathwaysShyur, L. -F. ; Lee, S. -H.; Chang, S. -T.; Lo, C. -P.; Kuo, Y. -H.; Wang, S. -Y.Phytomedicine 18, 16-24
1002012Taxol, camptothecin and beyond for cancer therapy.Lee, W. -L.; Shiau, J. -Y.; Shyur, L. -F. Advances in Botanical Research 62, 133-178
1012023The critical role of galectin-12 in modulating lipid metabolism in sebaceous glandsTsao, C.-H.; Hsieh, W.-C.; Lin, F.-J.; Yang, R.-Y.; Chang, M.-T.; Apaya, M. K.; Shyur, L.-F. ; Ke, L.-Y.; Zouboulis, C. C.; Liu, F.-T. Journal of Investigative Dermatology 143(6), 913-924.e4
1022005The distinct effects of a butanol fraction of Bidens pilosa plant extract on the development of Th1-mediated diabetes and Th2-mediated airway inflammation in miceChang, C. L. T.; Kuo, H. K.; Chang, S. L.; Chiang, Y. M.; Lee, T. H.; Wu, W. M.; Shyur, L. F. ; Yang, W. C. JOURNAL OF BIOMEDICAL SCIENCE 12(1), 79-89
1032003Tissue Array Transgene Expression System for the Evaluation of Effect of Medicinal Herbs on Wound-healingWang, J. -H.; Lin, K. -F.; Benson, S. A.; Sun, S. -J.; Cheng, W. -M.; Wang, S. -Y.; Shyur, L. -F. ; Yang, N. -S. Journal of Genetics and Molecular Biology 14(3), 133-144
1042020Transformation and Characterization of Δ12-Fatty Acid Acetylenase and Δ12-Oleate Desaturase Potentially Involved in the Polyacetylene Biosynthetic Pathway from Bidens pilosaChen, Po-Yen; Hsieh, Mi-Jou; Tsai, Yung-Ting; Chung, Hsiao-Hang; Shyur, Lie-Fen ; Hsieh, Cheng-Han; To, Kin-Ying Plants 9(11), 1483
1052009Truncated 1,3-1,4-beta- D-glucanaseShyur, L. -F. ; Wen, T. -N.; Lee, S. -H.; Yang, N. -S.US patent issued No. 7,527,958 No. 7,527,958
1062009Truncated form of fibrobacter succinogenes 1,3-1, 4-β-d-glucanase with improved enzymatic activity and thermo-tolerance (提高酵素比活性及熱耐受性之1,3-1,4-beta-D-葡聚醣酵素)Shyur, L. -F. ; Chen, J. -L.; Yang, N. -S. US patent(No. 7037696) and ROC patent(No. 201683) (Two technology licensing/transfer to local biotech companies)
1072000Truncated form of fibrobacter succinogenes 1,3-1, 4-β-d-glucanase with improved enzymatic activity and thermo-tolerance (提高酵素比活性及熱耐受性之1,3-1,4-beta-D-葡聚醣酵素)Shyur, L. F. ; Chen, J. L.; Yang, N. S. US patent(No. 7037696) and ROC patent(No. 201683)
1082006Use of Anoectochilus formosanus plant extracts and their derived fractions as herbal medicines or nutraceutical supplements for chemoprevention or treatment of human malignanciesShyur, L. -F. ; Yang, N. -S.; Kang, P. -L.; Sun, S. -J.; Wang, S. -Y.(US patent issued No. 7033617; Singapore patent issued No. 120937; PRC patent issued No. CN ZL03158682. 1) (One technology licensing/transfer to local biotech company) 7,033,617
1092009Use of Anoectochilus formosanus plant extracts and their derived fractions as herbal medicines or nutraceutical supplements for tumor prevention/treatmentShyur, L.-F. ; Yang, N.-S.; Kang, P.-L.; Sun, S.-J.; Wang, S.-Y.Australia patent issued No. AU 2003244587 澳洲專利
1102009Use of Anoectochilus formosanus plant extracts and their derived fractions as herbal medicines or nutraceutical supplements for tumor prevention/treatmentShyur, L. -F. ; Yang, N. -S.; Kang, P. -L.; Sun, S. -J.; Wang, S. -Y.PRC patent issued No. CN ZL03158682. 1 中國專利
1112010Use of Anoectochilus formosanus plant extracts and their derived fractions as herbal medicines or nutraceutical supplements for tumor prevention/treatmentShyur, L. -F. ; Yang, N. -S.; Kang, P. -L.; Sun, S. -J.; Wang, S. -Y.Malaysia patent issued No. PI20032638
1122020White sweet potato ameliorates hyperglycemia and regenerates pancreatic islets in diabetic miceShih, C.-K.; Chen, C.-M.; Varga, V.; Shih, L.-C.; Chen, P.-R.; Lo, S.-F.; Shyur, L.-F. ; Li, S.-C.Food & Nutrition Research 64, 3609

 

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